UK’s Kate and William to spend Christmas Day with her parents

LONDON (Reuters) – Britain’s Prince William and his pregnant wife Kate will spend Christmas Day with her parents, their office said on Saturday, in a break with the tradition of royals joining Queen Elizabeth at her country estate at Sandringham.

The Duke and Duchess of Cambridge will celebrate in private with Carole and Michael Middleton at their home in the village of Bucklebury, about 50 miles west of London.

“The Duke and Duchess of Cambridge will spend Christmas Day privately with the Middleton family,” a St James’s Palace spokesman said.

The couple’s decision was taken with the approval of the Queen. They are expected to visit Sandringham, in eastern England, for part of the Christmas holiday.

Kate, 30, who married the second-in-line to the throne in April 2011, spent four days in hospital this month with an acute form of morning sickness.

Members of the British royal family usually spend Christmas at Sandringham and stay until February, following a custom set by Queen Elizabeth’s father and grandfather. Kate and William spent Christmas there last year, meeting scores of wellwishers.

The Middletons are likely to join millions of Britons in watching Queen Elizabeth’s annual Christmas broadcast, a tradition that her grandfather George V started in 1932.

For the first time, the monarch has recorded her television broadcast in 3D. It will be shown at 1500 GMT on December 25.

(Reporting by Peter Griffiths; Editing by Kevin Liffey)

Celebrity News Headlines – Yahoo! News

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Genetic Gamble : Drugs Aim to Make Several Types of Cancer Self-Destruct

C.J. Gunther for The New York Times

Dr. Donald Bergstrom is a cancer specialist at Sanofi, one of three companies working on a drug to restore a tendency of damaged cells to self-destruct.

For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr. Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged.”

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumor was wrapped around a cord that connects the testicle to the abdomen. “I was shocked,” he said in an interview this summer.

Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi’s drug because the tumors nearly always have the exact genetic problem the drug was meant to attack — a fusion of two large proteins. If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.

“For us, this is a go/no-go situation,” said Laurent Debussche, a Sanofi scientist who leads the company’s research on the drug.

The genetic alteration the drug targets has tantalized researchers for decades. Normal healthy cells have a mechanism that tells them to die if their DNA is too badly damaged to repair. Cancer cells have grotesquely damaged DNA, so ordinarily they would self-destruct. A protein known as p53 that Dr. Gary Gilliland of Merck calls the cell’s angel of death normally sets things in motion. But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to reanimate p53 in cancer cells so they will die on their own.

The p53 story began in earnest about 20 years ago. Excitement ran so high that, in 1993, Science magazine anointed it Molecule of the Year and put it on the cover. An editorial held out the possibility of “a cure of a terrible killer in the not too distant future.”

Companies began chasing a drug to restore p53 in cells where it was disabled by mutations. But while scientists know how to block genes, they have not figured out how to add or restore them. Researchers tried gene therapy, adding good copies of the p53 gene to cancer cells. That did not work.

Then, instead of going after mutated p53 genes, they went after half of cancers that used the alternative route to disable p53, blocking it by attaching it to a protein known as MDM2. When the two proteins stick together, the p53 protein no longer functions. Maybe, researchers thought, they could find a molecule to wedge itself between the two proteins and pry them apart.

The problem was that both proteins are huge and cling tightly to each other. Drug molecules are typically tiny. How could they find one that could separate these two bruisers, like a referee at a boxing match?

In 1996, researchers at Roche noticed a small pocket between the behemoths where a tiny molecule might slip in and pry them apart. It took six years, but Roche found such a molecule and named it Nutlin because the lab was in Nutley, N.J.

But Nutlins did not work as drugs because they were not absorbed into the body.

Roche, Merck and Sanofi persevered, testing thousands of molecules.

At Sanofi, the stubborn scientist leading the way, Dr. Debussche, maintained an obsession with p53 for two decades. Finally, in 2009, his team, together with Shaomeng Wang at the University of Michigan and a biotech company, Ascenta Therapeutics, found a promising compound.

The company tested the drug by pumping it each day into the stomachs of mice with sarcoma.

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Preoccupations: When Relocation Is a Way of Life

ON New Year’s Day, the company I work for, Four Seasons Hotels and Resorts, will move me from Washington to Paris, where I will become a regional vice president of the company and general manager of the Hotel George V, which it manages.

Daniel Rosenbaum for The New York Times

Gathering the frequent-mover miles: From left are Christian and Meg Clerc, and their daughters, Eleanor and Georgia, at home in Washington.

My wife, Meg, teaches at a Montessori school. She and our teenage daughters, Eleanor and Georgia, will reunite with me at the end of the school year. It’s the seventh move for Meg and me: about every three years for the last two decades, we’ve packed and unpacked, and left newfound schools, friends, cars, dry cleaners, banks and homes, and found newer ones.

If you want to advance in the hotel industry, you’d better be able to check “yes” next to the box that asks, “Willing to relocate?” Mobility must be in your DNA if you want to move up. Originally from Switzerland, I myself have moved eight times over 25 years of working in hotels, rising from hotel restaurant food runner to hotel general manager: from Gstaad to Lausanne, Switzerland; then to Washington, Rome, Paris and back to Washington, then to Puerto Vallarta, Mexico, and to Chicago and Washington once more. Eleanor, now 17, was born in Rome. Georgia, 14, joined the journey on our first assignment in Washington.

Meg knew the score — and welcomed the global lifestyle — when she married me. In fact, she chose a mobile career herself, knowing that there would be Montessori schools worldwide.

The company provides good logistical support when it moves its employees. And on the home front, we have grown increasingly adaptive, and the moves have become easier over the years. The process begins when I first realize that a move may be in the works. Meg and I go out for lunch or coffee and review our trusty to-do list to become move-ready. Then we take our daughters out to lunch or dinner and broach the subject, beginning with “How would you feel if we moved to X?”

The worst reaction was when we planned to move back to Washington from Chicago less than a year after arriving there from Mexico. We thought the girls would be thrilled to reunite with friends in a familiar place. We thought wrong. In unison, they broke out in tears; they had just made new friends and were starting to fit in again.

Meg, so skilled at working with children as a teacher, had them talk about the roots of their fears and sadness, which usually revolve around establishing new social networks. I, racked by guilt about upsetting their cart again, blurted that they could get the puppy they had been begging for. (I had been adamantly opposed until then.) The tears stopped. Needless to say, our pup, Snickers, will be moving to Paris, too.

To stay sane at relocation time, we keep the house we’re in as homey as possible until we move, then turn the new house into a home as fast as we can. That way, we don’t have to stare at cardboard boxes on both ends of the trip. We can pack in two weeks.

Moving makes you prioritize what’s important. You have to decide what’s crucial enough to bring, and what’s marginal enough to leave behind. With friends, you have to choose those to see before you go, and the ones you want to stay in touch with after the move.

Each of us has certain things we take along — our “transitional objects.” For example, I need the big wooden credenza that’s been in my family for generations, a great coffee machine, my A.S. Roma soccer-club shirt and my watch box — after all, I am Swiss. For Meg, it’s not about things, but about creating a cozy, well-lit new space. The girls still bring their favorite stuffed animals along with photos, but their most important transitional object is each other.

BUILDING a new network of friends can be as daunting for Meg and me as it is for the girls. We’ve found friends among new work colleagues and through tight-knit expat communities. But there’s a danger of getting stuck in a cultural bubble and never befriending local people.

Our moves have brought us a great appreciation of cultural differences. The ability to adapt quickly to change helps in all kinds of situations. The moves have also prepared our daughters to make new friends quickly. Still, we wonder and worry how it will affect their future relationships. Will they have trouble forming long-lasting bonds?

We find inspiration, meanwhile, in
the lyrics of “You’re My Home,” the Billy Joel song: “I never had a place that I could call my very own, but that’s
all right, my love, ’cause you’re my home.”

As told to Perry Garfinkel.

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Appeals court puts hold on California gay conversion ban

A federal appeals court Friday put a hold on a new state law intended to prevent therapists from trying to change a minor's sexual orientation, dealing a setback to gay rights groups.

A three-judge panel of the U.S. 9th Circuit Court of Appeals agreed to block the law, scheduled to take effect Jan. 1, pending a decision on its constitutionality.

"This is a very good sign for our clients," said Mathew Staver, found of Liberty Counsel, a religious liberties group that sued to block the law, arguing that it violates free speech rights. "To get an injunction pending appeal is a very difficult thing to do."

A spokeswoman for state Atty. Gen. Kamala D. Harris said Harris would "vigorously defend" a law that banned what she termed an "unsound and harmful practice."

The law would subject psychologists, psychiatrists and other mental health professionals to discipline by their licensing boards for providing minors therapy to change their sexual orientation. The state and many professional groups say the therapy is ineffective and potentially dangerous.

A District Court judge initially rejected the suit by Liberty Counsel, whose clients include a 15-year-old boy undergoing the therapy. The Christian-oriented legal group appealed that decision to the 9th Circuit.

The judges who are hearing the case are Alfred T. Goodwin, appointed by President Nixon; Edward Leavy, a Reagan appointee; and Milan D. Smith Jr., named to the court by President George W. Bush.

Staver, calling the preliminary injunction "very welcome news," said it was "never routine" and granted only in extraordinary situations when the court believes an appeal has a "likelihood of success."

UC Irvine Law School Dean Erwin Chemerinsky, who believes that the law is constitutional, said its opponents "won this round."

"This doesn't determine the ultimate outcome by the 9th Circuit," the constitutional law expert said. "It still has to rule on the merits, and it could well go to the Supreme Court. But obviously this is a preliminary loss for supporters of the law."

California's ban on trying to change a minor's sexual orientation, the first of its kind in the nation, has divided the lower courts. The federal judge in Sacramento who refused to block the law was appointed by President Obama. She concluded that it did not violate the 1st Amendment. Her colleague on the same bench, appointed by President George H.W. Bush, concluded that it was likely that the law infringed on free speech protections.

Communication between professionals and their clients generally has less 1st Amendment protection than other forms of speech. For instance, a lawyer or doctor who negligently gives bad advice may be found liable for malpractice, and licensing requirements for professionals may be restrictive.

The Supreme Court upheld a law that required doctors to tell patients about potential harmful effects of an abortion, but the 9th Circuit blocked a federal law designed to prevent doctors from discussing the benefits of marijuana with patients.

Therapy to change sexual orientation may involve psychoanalysis, cognitive behavioral treatment and religious and spiritual counseling. Some therapists have practiced aversion therapy using hormone treatments and nausea-inducing drugs to combat sexual impulses.

A task force report by the American Psychological Assn. in 2009 said the therapy could trigger depression, suicide and substance abuse, but also noted that there was scant research on the issue.

The new law was supported by the California Psychological Assn., the California chapter of the National Assn. of Social Workers and the California Division of the American Assn. for Marriage and Family Therapy.

Gay rights activists Friday minimized the setback and noted that the court has agreed to review the law on a fast track.

"Every leading medical and mental health organization has warned therapists and parents that these practices do not work and put young people at risk of serious harm, including depression and suicide," said Shannon Minter, legal director of the National Center for Lesbian Rights. "No young person should be subjected to these dangerous practices, and no licensed therapist should be permitted to engage in practices that cause such serious harm."

maura.dolan@latimes.com

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A Google-a-Day Puzzle for Dec. 22

Our good friends at Google run a daily puzzle challenge and asked us to help get them out to the geeky masses. Each day’s puzzle will task your googling skills a little more, leading you to Google mastery. Each morning at 12:01 a.m. Eastern time you’ll see a new puzzle posted here.

SPOILER WARNING:
We leave the comments on so people can work together to find the answer. As such, if you want to figure it out all by yourself, DON’T READ THE COMMENTS!

Also, with the knowledge that because others may publish their answers before you do, if you want to be able to search for information without accidentally seeing the answer somewhere, you can use the Google-a-Day site’s search tool, which will automatically filter out published answers, to give you a spoiler-free experience.

And now, without further ado, we give you…

TODAY’S PUZZLE:

Note: Ad-blocking software may prevent display of the puzzle widget.

Ken is a husband and father from the San Francisco Bay Area, where he works as a civil engineer. He also wrote the NYT bestselling book "Geek Dad: Awesomely Geeky Projects for Dads and Kids to Share."

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‘Skyfall’ Will Open January 21 in China, Won’t Face ‘Hobbit’

LOS ANGELES (TheWrap.com) – Global blockbuster “Skyfall” will open on January 21 in China, a person with knowledge of the situation confirmed to TheWrap Friday.

A strong run in China will be critical if “Skyfall” is to hit $ 1 billion at the worldwide box office.

The date means that Sony and MGM’s newest 007 film will likely roll out ahead of Warner Bros.‘ Middle-earth epic “The Hobbit,” which is expected to open in February, after China’s February 9 Golden Week holidays are under way.

Chinese officials have aggressively protected their domestic film industry this year, in some case by slotting major U.S. films against each other to reduce their box-office impact.

The studios had been waiting for confirmation from on a release date since opening the 23rd James Bond thriller in the U.K. on October 26.

The two studios had been in a similar situation with two box-office hits earlier this year, when “Dark Knight Rises” and “The Amazing Spider-Man” both opened on August 27. That cut their grosses, but China still became the No. 1 foreign market for both films, with “Dark Knight Rises” taking in $ 52 million for Warner Bros. and “Spider-Man” taking in $ 48 million for Sony.

“Skyfall,” which stars Daniel Craig, has a good shot at becoming the first Bond movie to hit the billion-dollar mark at the box office. But it will need strong performances in China and Japan where it has taken in more than $ 16.7 million since opening three weeks ago – to get there.

The film has made more at the box office than any of the 22 previous James Bond films, with $ 953 million globally since opening on October 26. The majority of that – $ 678 million – has come from overseas. The top market is the U.K., where “Skyfall” is that country’s biggest movie ever with more than $ 158 million.

Movies News Headlines – Yahoo! News

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Vernice D. Ferguson, Leader and Advocate of Nurses, Dies at 84

Vernice D. Ferguson, who fought for greater opportunities, higher wages and more respect for nurses as a longtime chief nursing officer for the Veterans Administration, died on Dec. 8 at her home in Washington. She was 84.

NYU Photobureau

Vernice D. Ferguson served at the Veterans Administration.

Her niece Hope Ferguson confirmed her death.

America faced a nursing shortage when Ms. Ferguson began overseeing the agency’s more than 60,000 nurses nationwide in 1980. Historically, the nursing ranks were overwhelmingly female, but as job opportunities began to expand for young women in the late 1970s, nursing, with its prospect of strenuous work, irregular hours and relatively low pay, was losing its appeal.

Doctors, most of whom were men, were paid far more and rarely discussed medical treatments with nurses, despite nurses’ hands-on knowledge of patients.

“What is good enough for the doctor is good enough for me and the nursing staff,” Ms. Ferguson was quoted as saying in the book “Pivotal Moments in Nursing: Leaders Who Changed the Path of a Profession,” by Beth Houser and Kathy Player. “Whatever the boys have, I am going to get the same thing for the girls.”

In 1981, Ms. Ferguson told National Journal, “Hospitals are going to have to rethink and restructure their policies to let nurses perform nursing services and let others attend to ‘hotel’ services,” like making beds and handling phone calls.

Ms. Ferguson helped establish an agency scholarship program to recruit and retain nurses and made educational programs that had been restricted to doctors open to nurses as well.

By 1992, when she left the agency — then the Department of Veterans Affairs — the number of registered nurses there with bachelor’s degrees or higher had more than doubled. Nurses’ salaries also increased throughout the field. In 1980, their average annual pay was $26,826 in 2008 dollars; in 2008, it was $66,973, according to the most recent survey of registered nurses.

Vernice Doris Ferguson was born on June 13, 1928, in Fayetteville, N.C. Her father was a minister in Baltimore, where she grew up, and her mother was a teacher. At a time when few black women attended college, Ms. Ferguson graduated from New York University with a nursing degree in 1950 and was awarded the Lavinia L. Dock prize for high scholastic standing. At the awards ceremony, the director of nursing refused to shake her hand, Ms. Houser and Ms. Player wrote.

Ms. Ferguson’s first job out of college was in a research unit financed by the National Institutes of Health at Montefiore Medical Center in the Bronx. She went on to be a co-author of papers in The American Journal of Nursing, The Journal of Clinical Nutrition and The Journal of Clinical Investigation.

She worked in several hospitals around the country, and from 1972 to 1980 was the chief of the nursing department of the Clinical Center at the National Institutes of Health. A brief marriage ended in divorce. Her survivors include a sister, Velma O. Ferguson, and several nieces and nephews.

After retiring in 1992, Ms. Ferguson was appointed senior fellow at the University of Pennsylvania School of Nursing.

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Hedge fund manager alleges Herbalife is 'pyramid scheme'

Herbalife Ltd. is girding for a fight against a Wall Street money man who's betting $1 billion that the company is nothing more than what he called a "pyramid scheme."

The Los Angeles maker of nutritional products rushed to defend itself Thursday against a hedge fund manager's accusation.

Hedge fund titan Bill Ackman accused Herbalife of paying its sales staff far more money to recruit new distributors than to actually sell its products.

That results in the roughly 2.6 million distributors at the bottom of the sales pyramid making little or no income, while a handful at the top hauls in millions, he said.

"This is the best-managed pyramid scheme in the history of the world," Ackman said.

The company denied the allegation and accused Ackman of trying to manipulate the stock. Herbalife shares slumped 10% on Thursday and are off 21% in the two days since Ackman announced that the company is in his sights.

"Today's presentation was a malicious attack on our business model based largely on outdated, distorted and inaccurate information," Herbalife said in a statement. "We are not an illegal pyramid scheme."

Herbalife, which bills itself as a so-called multilevel marketer, has beaten back similar accusations in the past. But the company has rarely faced a nemesis such as Ackman.

The 46-year-old billionaire has fashioned a career on high-stakes gambits in controversial companies. His fund firm, Pershing Square Capital Management, manages $12 billion.

Showdowns between companies and skeptical investors historically play out behind closed doors, especially in the normally sleepy pre-holiday period.

But in a measure of the aggressive tactics favored by an emerging breed of activist investors, Ackman launched a public blitzkrieg Thursday. He gave a flashy multimedia presentation to a packed conference room in New York that was streamed live on the Internet.

"I've never seen anything quite like it," said Timothy Ramey, an analyst at D.A. Davidson & Co. "I've never seen an investor spend 31/2 hours of time at a major venue being webcast and then make TV appearances to make his point. It's the largest orchestrated bull or bear case that I've ever seen."

The brawl has potential repercussions for both sides.

Ackman claimed to have spent one year doing intensive research on Herbalife's operations, an unusually extended period given Wall Street's thirst for immediate results.

Earlier this year, Ackman began betting that Herbalife's stock would fall sharply.

His fund is "shorting" more than 20 million shares of the company. In a short sale, an investor borrows stock and sells it immediately, hoping to later buy the shares at a reduced price and return them to their actual owner.

Ackman promised to donate all profit from his Herbalife bet to charity, and portrayed his public diatribe as intended for the public good.

"I'm very fortunate to have the means to pursue this," he said. "I am independently wealthy. When I believe in something, I can say what I want and do what is right."

For Herbalife, the fight threatens to damage its credibility among investors who have always been sensitive to claims that its business is illegitimate.

Herbalife, which was founded in 1980, sells a line of diet powders, bars, drinks and vitamins through a network of independent distributors in more than 80 countries. The company reported sales of $3.5 billion in 2011.

Its chief executive, Michael O. Johnson, was the highest paid executive in the United States last year, hauling in more than $89 million in salary, exercised stock options and other compensation, according to GMI Ratings, a corporate governance firm.

The company has fought criticism of its business model throughout its existence.

In 2008, for example, self-proclaimed fraud buster Barry Minkow shorted Herbalife's stock and then accused the company of a host of misdeeds. The company survived those accusations and Minkow ultimately went to prison on unrelated charges.

This was the second time this year that investors punished Herbalife because of questions about its business practices. Herbalife shares fell 20% in May after hedge fund operator David Einhorn asked pointed questions during an earnings call.

"We operate at the highest ethical and quality standards, and our management and our board are constantly reviewing our business practices and products," Herbalife said. "We also hire independent, outside experts to ensure our operations are in full compliance with laws and regulations."

Ackman and Herbalife engaged in a bitter and bizarre war of words, with Johnson saying the United States will "be better when Bill Ackman is gone."

Ackman interpreted the statement as a threat and said he has hired a security firm to protect him.

stuart.pfeifer@latimes.com

walter.hamilton@latimes.com

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A Google-a-Day Puzzle for Dec. 21

Our good friends at Google run a daily puzzle challenge and asked us to help get them out to the geeky masses. Each day’s puzzle will task your googling skills a little more, leading you to Google mastery. Each morning at 12:01 a.m. Eastern time you’ll see a new puzzle posted here.

SPOILER WARNING:
We leave the comments on so people can work together to find the answer. As such, if you want to figure it out all by yourself, DON’T READ THE COMMENTS!

Also, with the knowledge that because others may publish their answers before you do, if you want to be able to search for information without accidentally seeing the answer somewhere, you can use the Google-a-Day site’s search tool, which will automatically filter out published answers, to give you a spoiler-free experience.

And now, without further ado, we give you…

TODAY’S PUZZLE:

Note: Ad-blocking software may prevent display of the puzzle widget.

Ken is a husband and father from the San Francisco Bay Area, where he works as a civil engineer. He also wrote the NYT bestselling book "Geek Dad: Awesomely Geeky Projects for Dads and Kids to Share."

Read more by Ken Denmead

Follow @fitzwillie and @wiredgeekdad on Twitter.

Read More..

Mission Impossible?: Can Tom Cruise Launch a Box-Office Franchise with ‘Jack Reacher’?

LOS ANGELES (TheWrap.com) – Paramount hopes it’s launching a franchise with “Jack Reacher,” the Tom Cruise action thriller that hits theaters Friday.

It will be tricky in a crowded holiday marketplace, and Cruise isn’t the box-office bonanza he once was. But one need only look back to last year’s “Mission: Impossible – Ghost Protocol” to see how it might work. That film opened to $ 12 million on December 16 and went on to make $ 209 million and nearly $ 700 million worldwide for Paramount.

“Jack Reacher” will be in about 3,200 theaters, and it will have plenty of competition. Universal’s Judd Apatow comedy “This Is 40″ opens wide Friday, and Paramount‘s ‘Guilt Trip” and Disney’s 3D re-release of “Monsters Inc.” opened Wednesday.

A slew of limited releases, led by Kathryn Bigelow’s “Zero Dark Thirty,” along with this year’s winner of the Palme d’Or at Cannes “Amour,” and tsunami survival tale “The Impossible” are also competing for moviegoers’ attention, along with a number of holdover hits.

No movie, though, will come close to catching reigning box-office champ “The Hobbit: An Unexpected Journey,” which remains in more than 4,000 theaters. Peter Jackson’s latest Middle-earth epic will take in north of $ 40 million, industry analysts say, with “Jack Reacher” and “This Is 40″ battling for second with less than half of that.

Warner Bros.’ “Hobbit” has rolled to $ 106 million in the U.S. since opening to $ 85 million last weekend. Its international total – $ 188 million as of Thursday – is even bigger.

In “Jack Reacher,” Cruise plays an ex-military investigator; the film is based on bestselling author Lee Child’s novel “One Shot” and written for the screen and directed by Christopher McQuarrie. It’s from David Ellison’s Paramount-based Skydance Productions and was produced for about $ 60 million by Cruise, Don Granger, Paula Wagner and Gary Levinsohn.

Robert Duvall and Richard Jenkins co-star in the PG-13 crime thriller, which has a 53 percent positive rating at Movie Review Intelligence.

No is expecting “Jack Reacher” to match “MI:4″ at the box office. The Reacher novels have a following, but nowhere near that of the “Mission Impossible” franchise. Cruise’s recent box-office record has been uneven, and the film’s Facebook and Twitter activity is not particularly strong.

“Jack Reacher” could wind up playing more like Cruise’s “Knight and Day,” which opened to $ 20 million and went on to make $ 76 million for Fox in 2010, or “Valkyrie,” which did $ 83 million in 2008 after opening to $ 21 million. Cruise was critically lauded for his foray earlier this year as an aging rock icon in the musical “Rock of Ages,” but that was one of the year’s bigger box-office duds.

“Jack Reacher” should play strongly with action fans, but Cruise’s personal problems could limit its broader appeal.

“I can’t imagine his divorce from Katie Holmes and the custody battle hasn’t hurt him some with women,” BoxOffice.com vice president and chief analyst Phil Contrino told TheWrap Thursday. “Actions fans will come out, but going beyond that demographic is going to be tough for him.”

On the other hand, Universal says that it tracking suggests “This Is 40″ will do quite well with women — and women over 25 in particular.

“This Is 40,” is, as the marketing campaign points out, a “sort of sequel” to Apatow’s “Knocked Up,” which opened to $ 30 million and went on to make nearly $ 150 million five years ago. Like “This Is 40,” that one was written and directed by Apatow and starred Paul Rudd and Leslie Mann.

“40″ is the fourth film Apatow has directed, all for Universal (“Funny People” and “40-Year-Old Virgin” are the other two). The ensemble cast also features Albert Brooks, John Lithgow, Megan Fox, Maude Apatow, Iris Apatow, Chris O’Dowd, Jason Segel, Melissa McCarthy and Lena Dunham.

It’s R-rated and has a 62 percent positive rating at Movie Review Intelligence. The production budget was $ 35 million.

“This looks like the strongest comedy of the season,” Jeff Bock, senior analyst at Exhibitor Relations told TheWrap, “but it’s still a bit of a wild card. It’s going to connect with the New York and L.A. crowds; the key will be whether the Heartland audiences embrace it or see it as a little too hip. It will take time to tell, because of the season.”

Films released at this time of year tend to open lower because the marketplace is so crowded – by Friday, 11 new films will have hit opened this week – and the fact that many potential moviegoers are districted by shopping and other holiday preps. On the other hand, they often show lasting power and make up what they don’t take in on the weekend with stronger showings on the weekdays.

“Things could well come in lower than people are expecting across the board this weekend,” Bock said, “but look for many of these movies to make it up over the holidays.”

Summit will be looking for that kind of slow build on “The Impossible,” the English-language film from Spain based on a true story about a family’s fight to survive the 2004 tsunami in Thailand. Ewan McGregor and Naomi Watts, who received a Best Actress nomination from SAG recently, star.

Summit is releasing it Friday in 15 theaters in New York, Los Angeles, Chicago, Philadelphia, Phoenix, San Francisco, Washington, D.C., and Toronto. The plan is to go nationwide early next year.

“The Impossible” already has taken in $ 52 million in Spain, the home of the real-life couple upon whom the story is based as well as director Juan Antonio Bayona (“The Orphanage”) and screenwriter Sergio Sanchez.

Other limited rollouts set for Friday include Paramount‘s 3D concert film “Cirque du Soleil: Worlds Away,” in 800 theaters; “On the Road,” IFC Films’ adaptation of the Jack Kerouac’s beat generation novel, in four theaters; and “Not Fade Away,” the Paramount Vantage tale of a group of 1960 New Jersey friends launching a rock band, written and directed by “Sopranos” creator David Chase, in three locations.

Sony’s “Zero Dark Thirty,” about the manhunt for Osama bin Laden, got off to a terrific start Wednesday. It racked up $ 124,848 from five theaters in its first day of release. That’s an average of $ 24,969, making it one of the biggest limited mid-week openings in history.

Movies News Headlines – Yahoo! News

Title Post: Mission Impossible?: Can Tom Cruise Launch a Box-Office Franchise with ‘Jack Reacher’?
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